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glossary:sox_18 [2007/09/07 04:24]
Pat O'Connor
glossary:sox_18 [2012/10/16 14:40] (current)
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 +Member of the Sox multi-gene family (Sry-related HMG-box gene). The testis-determining gene SRY (480000) encodes a transcription factor characterized by a DNA-binding motif known as the HMG (high mobility group) domain. The SOX gene family consists of genes related to SRY, with a sequence identity of more than 60% to the SRY HMG box. See 600898.
  
 +Identified as responsible for/​involved in the development of Hypotrichosis [[:​Lymphedema]] Telangiectasia Syndrome
 +
 +Researchers at the Institute for Molecular Bioscience have found that when new [[blood vessels]] form – in developing embryos and in [[glossary:​tumor|tumours]] – a gene, known as Sox18, switches on for just 48 hours. Dr Koopman, of the University of Queensland in a study done in 2000 said "The gene regulates blood vessel development and could allow the effective '​starving'​ of tumours reducing their ability to grow." ​
 +
 +See also: 
 +
 +*  [[:​Lymphedema]]
 +
 +*  [[:​Pathophysiology of Lymphedema]]
 +
 +*  [[http://​www.lymphedemapeople.com/​thesite/​lymphedema_genetics.htm| Lymphedema Genetics]]
 +
 +*  [[http://​www.lymphedemapeople.com/​phpBB2/​viewforum.php?​f=16 |Genetics, Research, Lymphangiogenesis,​ Angiogenesis ]]
glossary/sox_18.txt · Last modified: 2012/10/16 14:40 (external edit)