A form of cutaneous T-cell lymphoma manifested by generalised exfoliative erythroderma, intense pruritus, peripheral lymphadenopathy, and abnormal hyperchromatic mononuclear cells in the skin, lymph nodes, and peripheral blood (sezary cells). In plain English Sézary syndrome is a type of cutaneous T-cell lymphoma, characterized by skin abnormalities, extreme itching, enlarged lymph glands, and abnormal blood cells.
Sézary syndrome is a type of lymphoma, which is a disease where lymphocytes (a type of white blood cells) increase to very large numbers in a person's blood. Sézary syndrome is a type of lymphoma known as a cutaneous T-cell lymphoma, meaning that it is a disease where the white blood cells known as T lymphocytes increase to large numbers.
Sézary syndrome can affect many organs. In early stage disease, the skin is the only organ affected; however, later stage disease can affect other organ systems.