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glossary:nephropathy

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glossary:nephropathy [2012/10/16 14:40] (current)
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 +Any [[kidney]] [[disease]]. For example, there is diabetic nephropathy,​ gouty nephropathy,​ HIV-associated nephropathy,​ ischemic nephropathy,​ sickle cell nephropathy,​and so on. From the Greek "​nephros"​ (kidney) + "​pathos"​ (disease).
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 +**Diabetic nephropathy**:​ The kidney disease associated with long-standing [[diabetes]]. Diabetic nephropathy is also called Kimmelstiel-Wilson disease (or Kimmelstiel-Wilson syndrome) or intercapillary glomerulonephritis.
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 +Diabetic nephropathy typically affects the network of tiny blood vessels (the microvasculature) in the glomerulus, a key structure in the kidney composed of [[capillary]] [[blood vessels]]. The glomerulus is critically necessary for the filtration of the [[blood]]. Features of diabetic nephropathy include the [[http://​www.lymphedemapeople.com/​thesite/​edema_nephrotic_syndrome.htm|nephrotic syndrome]] with excessive filtration of [[protein]] into the urine ([[proteinuria]]),​ high [[blood pressure]] ([[hypertension]]),​ and progressively impaired kidney function. When it is severe, diabetic nephropathy leads to kidney failure, end-stage renal disease, and the need for chronic dialysis or a kidney transplant.
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 +The name Kimmelstiel-Wilson disease is often used. It honors Paul Kimmelstiel (1900-70), a German-born pathologist in the US, and Clifford Wilson (1906-), an English physician.
  
glossary/nephropathy.txt ยท Last modified: 2012/10/16 14:40 (external edit)