Mupirocin is used to treat certain skin infections (e.g., impetigo). It is an antibiotic that works by stopping the growth of certain bacteria. Mupirocin is an antibiotic produced through fermentation of Pseudomonas fluorescens and inhibits bacterial protein synthesis by binding to bacterial isoleucyl t-RNA synthetase. Mupirocin shows little risk of selection of resistant bacteria if used as prescribed. Mupirocin has bacteriostatic properties at minimum inhibitory concentrations and bactericidal properties at the higher concentrations reached when applied locally.
Following intravenous or oral administration, mupirocin is rapidly metabolised to the inactive monic acid. Activity:
Mupirocin ointment shows in vivo activity against Staphylococcus aureus (including methicillin-resistant strains), S. epidermidis and beta-haemolytic Streptococcus species.