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glossary:membranous_nephropathy

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glossary:membranous_nephropathy [2012/10/16 14:40] (current)
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 +(1) A frequent type of primary glomerular [[disease]] -- a disease affecting the glomerulus, the tiny ball-shaped structure in the [[kidney]] composed of [[capillary]] [[blood vessels]] that is actively involved in the filtration of the [[blood]] to form urine. The main sign of the disease is marked [[proteinuria]] ([[protein]] in the urine). ​
  
 +About 40% of people with membranous nephropathy progress to end-stage renal failure after 10 years. The majority (80%) of cases are primary, meaning the cause is not known. The remaining cases are secondary to conditions such as [[cancer]], [[infection]],​ and drug side effects. ​
 +
 +Membranous nephropathy is a glomerular immune-complex disease. Immune deposits form in the glomerular basement membrane that cause a membrane-like thickening. The constituent immune complexes consist of IgG. Cells called podocytes and their [[membrane]]-associated proteins play a pivotal role in the development of the disease by providing antigenic targets for circulating antibodies to form the glomerular immune deposits. Membranous nephropathy is also called membranous glomerulonephritis.
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 +The disease can occur before birth due to transmission of antibodies from the mother to the baby. The antibodies are directed against an [[antigen]] in podocytes called neutral endopeptidase (NEP). Mutations that truncate (shorten) the metallomembrane endopeptidase (MME) [[gene]], which encodes NEP, have been found to cause the neonatal form of this disease.
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 +(2) Alternative Names - Membranous glomerulonephritis;​ Membranous GN; Extramembranous glomerulonephritis;​ Glomerulonephritis - membranous
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 +Definition - Membranous nephropathy is a kidney disorder which involves changes and inflammation of the structures inside the kidney that help filter waste and fluids. The inflammation leads to problems with kidney function.
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 +Causes - Membranous nephropathy is caused by thickening of part of the glomerular basement [[membrane]]. Glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood. The exact reason for this thickening is not known.
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 +It is one of the most common causes of nephrotic syndrome. The condition may be a primary kidney disease of uncertain origin, or it may be associated with other conditions.
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 +The following increase your risk for this condition: ​
 +
 +  * Exposure to substances or medications,​ including gold, mercury, penicillamine,​ trimethadione,​ and [[skin]]-lightening creams
 + 
 +  * Hepatitis B
 + 
 +  * Malaria
 + 
 +  * [[Non-Hodgkin'​s lymphoma]]
 + 
 +  * Solid cancerous tumors
 + 
 +  * Systemic [[lupus]] erythematosus
 + 
 +  * Syphilis
 + 
 +See also: [[http://​www.lymphedemapeople.com/​thesite/​edema_nephrotic_syndrome.htm|Nephrotic Syndrome]]
glossary/membranous_nephropathy.txt ยท Last modified: 2012/10/16 14:40 (external edit)