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glossary:macrovascular_disease

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glossary:macrovascular_disease [2012/10/16 14:40] (current)
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 +(1) Macrovascular disease: [[Disease]] of the large [[blood vessels]], including the coronary [[arteries]],​ the [[aorta]], and the sizable arteries in the brain and in the limbs. Macrovascular disease is by contrast to microvascular disease. In persons with [[diabetes]],​ chronic [[hyperglycemia]] (assessed by glycosylated hemoglobin level) is related to the development of microvascular disease; however, the relation of glycosylated [[hemoglobin]] to macrovascular disease is less clear.
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 +Common Misspellings:​ macrovascular diease, macrovascular desease ​
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 +(2) Coronary microvascular disease (MVD) affects the heart'​s smallest coronary arteries. Coronary MVD occurs in the heart'​s tiny arteries when:
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 +Plaque (plak) forms in the [[arteries]]. Plaque is made up of fat, [[cholesterol]] (ko-LES-ter-ol),​ calcium, and other substances found in the [[blood]]. It narrows the coronary arteries and reduces [[blood flow]] to the heart muscle. As a result, the [[heart]] doesn'​t get the oxygen it needs. This is known as ischemic (is-KE-mik) heart disease, or heart disease. In coronary MVD, [[plaque]] can scatter, spread out evenly, or build up into blockages in the tiny coronary arteries. ​
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 +The arteries spasm (tighten). Spasms of the small coronary arteries also can prevent enough oxygen-rich blood from moving through the arteries. This too can cause ischemic heart disease. ​
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 +The walls of the arteries are damaged or diseased. Changes in the arteries'​ cells and the surrounding muscle [[tissue]]s may, over time, damage the arteries'​ walls.
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 +Coronary MVD is a new concept. It's different from traditional coronary artery disease (CAD). In CAD, plaque builds up in the heart'​s large arteries. This buildup can lead to blockages that limit or prevent oxygen-rich blood from reaching the heart muscle. ​
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 +In coronary MVD, however, the heart'​s smallest arteries are affected. Plaque doesn'​t always create blockages as it does in CAD. For this reason, coronary MVD also is called nonobstructive CAD.
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 +No one knows whether coronary MVD is the same as MVD linked to other diseases, such as [[diabetes]]. ​
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glossary/macrovascular_disease.txt ยท Last modified: 2012/10/16 14:40 (external edit)