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glossary:lymphocytopenia

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glossary:lymphocytopenia [2008/04/16 15:30]
Pat O'Connor
glossary:lymphocytopenia [2012/10/16 14:40] (current)
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 +====== Lymphocytopenia:​ ======
 +(1)A smaller than normal number of [[white blood cells]], [[lymphocytes]],​ in the blood circulation,​ occuring as a [[blood]] disorder or in association with nutritional deficiency, [[cancer]], or [[infectious mononucleosis]].
  
 +(2)Lymphocytopenia is a total lymphocyte count of < 1000/μL in adults or < 3000/μL in children < 2 yr. Sequelae include opportunistic [[infection]]s and an increased risk of [[malignant]] and [[autoimmune]] disorders. If the [[CBC]] reveals lymphocytopenia,​ testing for immunodeficiency and analysis of [[lymphocyte]] subpopulations should follow. Treatment is directed at the underlying cause. ​
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 +The normal lymphocyte count in adults is 1000 to 4800/μL; in children < 2 yr, 3000 to 9500/μL. At age 6 yr, the lower limit of normal is 1500/μL. Both B and [[T cell]]s are present in the peripheral [[blood]]; about 75% of the lymphocytes are T cells and 25% [[B cell]]s. Because lymphocytes account for only 20 to 40% of the total WBC count, lymphocytopenia may go unnoticed when WBC count is checked without a differential.
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 +Almost 65% of blood T cells are CD4+ (helper) T cells. Most patients with lymphocytopenia have a reduced absolute number of T cells, particularly in the number of CD4+ T cells. The average number of CD4+ T cells in adult blood is 1100/μL (range, 300 to 1300/μL), and the average number of cells of the other major T-cell subgroup, CD8+ (suppressor) T cells, is 600/μL (range, 100 to 900/μL).
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 +See also: [[Lymphopenia]]
glossary/lymphocytopenia.txt · Last modified: 2012/10/16 14:40 (external edit)