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glossary:lupus

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glossary:lupus [2007/09/26 00:23]
Pat O'Connor created
glossary:lupus [2012/10/16 14:40] (current)
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 +A [[chronic]] inflammatory condition caused by an [[autoimmune disease]]. An autoimmune disease occurs when the body's tissues are attacked by its own [[immune system]]. Patients with lupus have unusual [[glossary:​antibody|antibodies]] in their [[blood]] that are targeted against their own body [[tissue]]s.
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 +Lupus can cause disease of the [[skin]], heart, lungs, kidneys, joints, and nervous system. When only the skin is involved, the condition is called discoid lupus. When internal organs are involved, the condition is called systemic lupus [[glossary:​Erythematous |erythematosus]] (SLE). Up to 10% of persons with discoid lupus (lupus limited to the skin) eventually develop the systemic form of lupus (SLE).
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 +SLE is eight times more common in women than men. The causes of SLE are unknown. However, [[glossary:​hereditary|heredity]],​ [[virus]]es,​ ultraviolet light, and drugs may all play a role.
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 +Eleven criteria have been established for the diagnosis of SLE:
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 +  * Malar (over the cheeks of the face) "​butterfly"​ rash
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 +  * Discoid skin rash: patchy redness that can cause scarring
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 +  * Photosensitivity:​ skin rash in reaction to sunlight exposure
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 +  * [[Mucous membrane]] ulcers: ulceration of the lining of the mouth, nose or throat
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 +  * Arthritis: 2 or more swollen, tender joints of the extremities
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 +  * Pleuritis/​pericarditis:​ [[inflammation]] of the lining [[tissue]] around the heart or lungs, usually associated with chest [[pain]] with breathing
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 +  * Kidney abnormalities:​ abnormal amounts of urine [[protein]] or cellular elements
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 +  * Brain irritation: manifested by seizures (convulsions) and/or psychosis
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 +  * Blood count abnormalities:​ low counts of white or [[red blood cells]], or platelets
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 +  * Immunologic disorder: abnormal immune tests include anti-DNA or anti-Sm (Smith) antibodies, falsely positive blood test for syphilis, anticardiolipin antibodies, lupus anticoagulant,​ or positive LE prep test
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 +  * Antinuclear antibody: positive ANA antibody testing
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 +The treatment of SLE is directed toward decreasing [[inflammation]] and/or the level of autoimmune activity. Persons with SLE can help prevent "​flares"​ of disease by avoiding sun exposure and by not abruptly discontinuing medications.
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 +Common Misspellings:​ lupos, lupis, lupas, lupis 
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glossary/lupus.txt ยท Last modified: 2012/10/16 14:40 (external edit)