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glossary:gangrene [2008/04/25 13:36]
Pat O'Connor
glossary:gangrene [2012/10/16 14:40] (current)
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 +====== Gangrene: ======
 +(1) [[Necrosis]] and death of [[tissue]] generally either from [[infection]]s,​ venous insufficiency,​ severe injury. Gangrene is the death and decay of tissue that usually occurs when the [[blood]] supply to the tissue is cut off by injury or [[infection]]. After the tissue is dead, [[bacteria]] may infect the [[tissue]] and cause decay. ​
 +
 +Gangrene may affect small areas, such as fingers or toes that have been frostbitten,​ or larger areas of tissue, such as part of the foot. People who have impaired [[blood flow]], such as people with [[diabetes]],​ may be at higher risk of gangrene if they have [[skin]] wounds and infections that are not treated promptly.
 +
 +Gangrene is treated by restoring [[blood flow]] to the affected area, treating any [[infection]],​ and removing the dead and dying tissue. If it is severe, gangrene sometimes requires that a part of the body, such as a finger, toe, or foot, be amputated.
 +
 +(2) The death of body tissue due to the loss of [[blood]] supply to that [[tissue]], sometimes permitting [[bacteria]] to invade it and accelerate its decay. ​
 +
 +The word "​gangrene"​ comes from the Greek "​ganggraina"​ denoting "an eating sore that ends in mortification"​ (of the flesh). ​
 +
 +Gas gangrene involves the invasion of a deep penetrating wound (in which the blood supply is compromised) by [[anaerobic organisms]] (bacteria that can survive with little or no oxygen) such as members of Clostridium family of bacteria. The bacteria generate gas and [[pus]]. Gas gangrene is an acute, painful, dangerous condition. ​
 +
 +Dry gangrene is the death of tissue due to vascular insufficiency without bacterial invasion. The tissue simply dries up and shrivels.
 +
 +(3) Gangrene is devided in four Types. Premary is Dry gangrene. If the [[blood flow]] is interrupted for a reason other than severe bacterial infection, the result is a dry gangrene. The early signs of dry gangrene are a dull ache and sensation of coldness in the area, along with pallor of the flesh. If caught early, the process can sometimes be reversed by [[vascular]] surgery. Second is Internal gangrene it section is a stub.In this gangrene the tissues become white. It is located inside the body, usually after [[surgery]] or [[trauma]]. Also called "white gangrene"​.Third is Wet gangrene like in dry gangrene, the [[blood flow]] is interrupted,​ but there is also a bacterial infection. Due to liquefactive [[necrosis]],​ liquid is released and last is Gas gangrene. [[Gas gangrene]] is a bacterial infection that produces gas within tissues in gangrene. It is a deadly form of gangrene usually caused by Clostridium perfringens bacteria. Treatment is usually surgical debridement and excision with amputation necessary in many cases. [[http://​www.lymphedemapeople.com/​thesite/​lymphedema_antibiotics.htm|Antibiotics]] alone are not effective because they do not penetrate ischemic muscles sufficiently. However, [[penicillin]] is given as an adjuvant treatment to surgery.
 +
 +Causes of Gas Gangrene ​
 +
 +1.Clostridium perfringens(bacteria ).
 +
 +2.Atherosclerosis
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 +3.[[Surgery]]
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 +4.[[Trauma]]
 +
 +5.Gastrointestinal [[malignancy]]
 +
 +6.[[Hypoalbuminemia]]
 +
 +7.Chronic alcoholism
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 +8.[[http://​www.lymphedemapeople.com/​thesite/​lymphedema_and_diabetes.htm|Diabetes]]
 +
 +Symptoms of Gas Gangrene ​
 +
 +1.Moderate to severe pain around a skin injury ​
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 +2.Progressive swelling around a skin injury ​
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 +3.Moderate to high fever 
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 +4.Sweating ​
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 +5.Increased heart rate (tachycardia) ​
 +
 +**See also:**
 +
 +[[Moist gangrene]]
 +
 +[[Dry gangrene]]
 +
 +See these pages: ​
 +
 +*  [[:​Infections Associated with Lymphedema]]
 +
 +*  [[http://​www.lymphedemapeople.com/​thesite/​lymphedema_complications_celluli.htm|Lymphedema Complications Cellulitis, Lymphangitis,​ infections]]  ​
  
glossary/gangrene.txt ยท Last modified: 2012/10/16 14:40 (external edit)