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glossary:degeneration [2012/10/16 14:40] (current)
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 +======Degeneration======
 +(1) Deterioration;​ change from a higher to a lower form, especially change of [[tissue]] to a lower or less functionally active form. When there is chemical change of the tissue itself it is true degeneration;​ when the change consists in the deposit of abnormal matter in the tissues, it is infiltration.
 +
 +(2) Med. deterioration in structure or function of cells, tissues, or organs, as in [[disease]] or aging
 +
 +=====Types of Degeneration=====
 +
 +==== Albuminoid degeneration ====
 +Cloudy [[swelling]],​ an early stage of degenerative change characterized by swollen, parboiled-appearing [[tissue]]s which revert to normal when the cause is removed.
 +
 +==== Ascending degeneration ====
 +Wallerian degeneration affecting centripetal nerve fibers and progressing toward the brain or spinal cord.
 +
 +==== Ballooning degeneration ====
 +Swelling of the cytoplasm in epidermal cells without vacuolization,​ enlarged or condensed nuclei and acantholysis. A characteristic of viral [[infection]]s of the [[skin]]. Called also koilocytosis.
 +
 +==== Calcareous degeneration ====
 +Degeneration of [[tissue]] with deposit of calcareous material.
 +
 +==== Caseous degeneration ====
 +Caseation (2). [[necrosis]] in which tissue is changed into a dry mass resembling cheese.
 +
 +==== Cerebromacular degeneration ====
 +(CMD), cerebroretinal degeneration ​
 +1. degeneration of brain cells and of the macula retinae.
 +2. any lipidosis with cerebral [[lesion]]s and degeneration of the macula retinae.
 +3. any form of neuronal ceroid-lipofuscinosis.
 +
 +==== Colloid degeneration ====
 +Degeneration with conversion of the tissues into a gelatinous or gumlike material.
 +
 +==== Congenital macular degeneration ====
 +Hereditary macular degeneration with a [[cyst]]like lesion that in the early stages resembles egg yolk.
 +
 +==== Crooke'​s hyaline degeneration ====
 +Crooke'​s hyalinization. Crooke'​s hyaline degeneration ​ Crooke'​s hyalinization.
 +
 +==== Cystic degeneration ====
 +Degeneration with formation of [[cyst]]s.
 +
 +==== Ddescending degeneration ====
 +Wallerian degeneration extending peripherally along nerve fibers.
 +
 +==== Disciform macular degeneration ====
 +A form of macular degeneration seen in persons over age 40, in which sclerosis involving the macula and retina is produced by hemorrhages between Bruch'​s [[membrane]] and the pigment epithelium.
 +
 +==== Fatty degeneration ====
 +Deposit of fat globules in a [[tissue]].
 +
 +==== Feathery degeneration ====
 +Said of hepatocytes;​ a hydropic change in hepatocytes which have suffered long-term exposure to cholestasis.
 +
 +==== Fibrinoid degeneration ====
 +Deposition or replacement with eosinophilic fibrillar or granular substance resembling fibrin.
 +
 +==== Fibroid degeneration ====
 +Degeneration into fibrous tissue.
 +
 +==== Fibrinous degeneration ====
 +[[Necrosis]] with deposit of fibrin within the [[cell]]s of the tissue.
 +
 +==== Gray degeneration ====
 +Degeneration of the white substance of the spinal cord, in which it loses myelin and assumes a gray color.
 +
 +==== Hepatolenticular degeneration ====
 +Wilson'​s disease. an inherited, progressive disorder of copper metabolism, with accumulation of copper in [[liver]], brain, [[kidney]], cornea, and other tissues; it is characterized by [[cirrhosis]] in the liver, degenerative changes in the brain, and a pigmented ring at the outer margin of the cornea.
 +
 +==== Hyaline degeneration ====
 +A regressive change in cells in which the [[cytoplasm]] takes on a homogeneous,​ glassy appearance; also used loosely to describe the histological appearance of tissues. Called also hyalinosis.
 +
 +==== Hhydropic degeneration ====
 +Calcareous degeneration ​ degeneration of tissue with deposit of calcareous material.
 +
 +==== Lattice degeneration ====
 +Of retina an often bilateral, usually benign asymptomatic condition, characterized by patches of fine gray or white intersecting lines in the peripheral retina, usually with numerous round punched-out areas of retinal thinning or retinal holes.
 +
 +==== Macular degeneration ====
 +Degenerative changes in the macula retinae.
 +
 +==== Mucoid degeneration ====
 +Degeneration with increased mucin which can be [[epithelial]] or mesenchymal in origin.
 +
 +==== Mucous degeneration ====
 +Degeneration with accumulation of mucus in [[epithelial]] tissues. Called also myxomatous degeneration.
 +
 +==== Myxomatous degeneration ====
 +Degeneration in which mucus accumulates in [[connective tissue]]s.
 +see mucous degeneration (above).
 +
 +==== Reticular degeneration ====
 +Extreme intracellular [[edema]] of epidermal cells, resulting in rupture and multilocular intraepidermal vesicles with septae formed by the remaining cell walls. Seen in acute [[inflammatory]] dermatoses.
 +
 +==== Spongy degeneration ====
 +On microscopic examination has the physical appearance of a sponge. Usually applied to tissue of the central nervous system, caused by the loss of myelin.
 +
 +==== Spongy degeneration of central nervous system ====
 +A rare hereditary form of leukodystrophy of early onset in which widespread demyelination and vacuolation of cerebral white matter gives it a spongy appearance; there is mental retardation,​ megalocephaly,​ atony of neck muscles, limb spasticity, and blindness, with death in infancy.
 +
 +==== Spongy degeneration ====
 +Of white a rare [[hereditary]] form of leukodystrophy of early onset in which widespread demyelination and vacuolation of cerebral white matter gives it a spongy appearance; there is mental retardation,​ megalocephaly,​ atony of neck muscles, limb spasticity, and blindness, with death in infancy.
 +
 +==== Striatonigral degeneration ====
 +A form of multiple system atrophy with nerve [[cell]] degeneration mainly in the region of the substantia nigra and the neostriatum;​ symptoms are similar to those of parkinsonism.
 +
 +==== Subacute combined degeneration ====
 +Of spinal cord  degeneration of posterior and lateral columns of the spinal cord, with various motor and sensory disturbances;​ it is due to vitamin B12 deficiency and usually associated with pernicious [[anemia]].
 +
 +==== Tapetoretinal degeneration ====
 +Degeneration of the pigmented layer of the retina.
 +
 +==== Transneuronal degeneration ====
 +Atrophy of certain neurons after interruption of afferent axons or death of other neurons to which they send their efferent output.
 +
 +==== Zenker'​s degeneration ====
 +Hyaline degeneration and necrosis of striated muscle.
  
glossary/degeneration.txt ยท Last modified: 2012/10/16 14:40 (external edit)