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glossary:burkitt_s_lymphoma

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glossary:burkitt_s_lymphoma [2013/01/30 09:46] (current)
Pat O'Connor created
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 +Burkitt'​s Lymphoma
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 +n. 
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 +(Medicine / Pathology) a rare type of tumour of the white blood cells, occurring mainly in Africa and associated with infection by Epstein-Barr virus.
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 +From **MedTerms:​**
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 +A type of non-Hodgkin lymphoma (NHL) that most often occurs in young people between the ages of 12 and 30, accounting for 40% to 50% of childhood NHL. The disease usually causes a rapidly growing tumor in the abdomen. Up to 90% of these tumors are in the abdomen. Other sites of involvement include the testis, sinuses, bone, lymph nodes, skin, bone marrow, and central nervous system.
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 +Burkitt lymphoma is a small noncleaved cell lymphoma of B-cell origin. About 25% of Burkitt lymphomas contain Epstein-Barr virus genomes. Burkitt lymphoma is due to a characteristic chromosomal translocation,​ usually a t(8;14) translocation or, less often, a t(8;22) or t(2;8) translocation. Each of these translocations juxtaposes the c-myc oncogene with immunoglobulin locus regulatory elements, resulting in the inappropriate expression of c-myc, a gene involved in cellular proliferation.
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 +Named for Denis Burkitt (1911-1993),​ a British surgeon who worked for many years in Africa. There he saw two children in rapid succession in 1957 with fast-growing,​ fatal tumors of the head and neck, assembled similar cases from other hospitals in Africa, and in 1958 reported what is now called Burkitt lymphoma.
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glossary/burkitt_s_lymphoma.txt ยท Last modified: 2013/01/30 09:46 by Pat O'Connor