Manifestation Experimental Lymphatic Insuffiency

Lymphangiogenic Gene Therapy, yellow nail syndrome, lymphatic vascular development, Intratumoral lymphatics, peritumoral lymphatics, stem cell research, Angiopoietins, VEGF, PIGF, FOXC1, FOXC2, Lymphatic Insufficiency. SOX18, lymphatic hyperplasia, Molecular lymphangiogenesis, PROX1, FLT3, Telan­giectasia, Lymphatic endothelial cells, adult vasculogenesis, LYVE1

Moderators: Birdwatcher, jenjay, Cassie, patoco, Senior Moderators

Manifestation Experimental Lymphatic Insuffiency

Postby patoco » Wed Sep 20, 2006 9:08 pm

Inflammatory Manifestations of Experimental Lymphatic Insufficiency.

July 2006

Tabibiazar R, Cheung L, Han J, Swanson J, Beilhack A, An A, Dadras SS,
Rockson N, Joshi S, Wagner R, Rockson SG.

Stanford Center for Lymphatic and Venous Disorders, Division of
Cardiovascular Medicine, Stanford University School of Medicine,
Stanford, California, United States of America.

BACKGROUND: Sustained lymph stagnation engenders a pathological response that is complex and not well characterized. Tissue inflammation in lymphedema may reflect either an active or passive consequence of impaired immune traffic.

METHODS AND FINDINGS: We studied an experimental model of acute post-surgical lymphedema in the tails of female hairless, immunocompetent SKH-1 mice. We performed in vivo imaging of impaired immune traffic in experimental, murine acquired lymphatic insufficiency. We demonstrated impaired mobilization of immunocompetent cells from the lymphedematous region. These findings correlated with histopathological alterations and large-scale transcriptional profiling results. We found intense inflammatory changes in the dermis and the subdermis. The molecular pattern in the RNA extracted from the whole tissue was dominated by the upregulation of genes related to acute
inflammation, immune response, complement activation, wound healing,
fibrosis, and oxidative stress response.

CONCLUSIONS: We have characterized a mouse model of acute, acquired lymphedema using in vivo functional imaging and histopathological correlation. The model closely simulates the volume response, histopathology, and lymphoscintigraphic characteristics of human acquired lymphedema, and the response is accompanied by an increase in the number and size of microlymphatic structures in the lymphedematous cutaneous tissues. Molecular characterization through clustering of genes with known functions provides insights into processes and signaling pathways that compose the acute tissue response to lymph
stagnation. Further study of genes identified through this effort will
continue to elucidate the molecular mechanisms and lead to potential
therapeutic strategies for lymphatic vascular insufficiency.

PMID: 16834456 [PubMed - as supplied by publisher]

Full text article:

http://medicine.plosjournals.org/perlse ... ed.0030254

--------------

Lymphedema People

http://www.lymphedemapeople.com
User avatar
patoco
Site Admin
 
Posts: 2175
Joined: Thu Jun 08, 2006 9:07 pm

Return to Genetics, Research, Lymphangiogenesis, Angiogenesis

Who is online

Users browsing this forum: No registered users and 4 guests


cron