Radiogenic Lymphangiogenesis in the Skin

Lymphangiogenic Gene Therapy, yellow nail syndrome, lymphatic vascular development, Intratumoral lymphatics, peritumoral lymphatics, stem cell research, Angiopoietins, VEGF, PIGF, FOXC1, FOXC2, Lymphatic Insufficiency. SOX18, lymphatic hyperplasia, Molecular lymphangiogenesis, PROX1, FLT3, Telan­giectasia, Lymphatic endothelial cells, adult vasculogenesis, LYVE1

Moderators: Birdwatcher, jenjay, Cassie, patoco, Senior Moderators

Radiogenic Lymphangiogenesis in the Skin

Postby patoco » Thu Jul 05, 2007 7:49 am

Radiogenic Lymphangiogenesis in the Skin

Am J Pathol. 2007 May 31

Jackowski S, Janusch M, Fiedler E, Marsch WC, Ulbrich EJ, Gaisbauer G,
Dunst J, Kerjaschki D, Helmbold P.

From the Departments of Dermatology,* Gynaecology, and Radiotherapy, Martin Luther University Halle-Wittenberg, Halle, Germany; the Department of Radiotherapy, University of Lübeck, Lübeck, Germany; the Institute of Pathology, Medical University of Vienna, Vienna, Austria;
and the Department of Dermatology, University of Heidelberg,
Heidelberg, Germany.

The time course of microvascular changes in the environment of
irradiated tumors was studied in a standardized human protocol. Eighty
skin biopsies from 40 patients with previously treated primary breast
cancer were taken from irradiated skin and corresponding contralateral
unirradiated control areas 2 to 8 weeks, 11 to 14 months, or 17+
months after radiotherapy (skin equivalent dose 30 to 40 Gy). Twenty-
two biopsies of 11 melanoma patients who had undergone lymph node
dissection were used for unirradiated control. We found an increase of
total podoplanin(+) lymphatic microvessel density resulting mainly
from a duplication of the density of smallest lymphatic vessels
(diameter <10 microm) in the samples taken 1 year after radiation. Our
findings implicate radiogenic lymphangiogenesis during the 1st year
after therapy. The numbers of CD68(+) and vascular endothelial growth
factor-C(+) cells were highly elevated in irradiated skin in the
samples taken 2 to 8 weeks after radiotherapy. Thus, our results
indicate that vascular endothelial growth factor-C expression by
invading macrophages could be a pathogenetic route of induction of
radiogenic lymphangiogenesis.

http://www.ncbi.nlm.nih.gov/sites/entre ... tailView...

**********

Pat O'Connor
Lymphedema People
http://www.lymphedemapeople.com
User avatar
patoco
Site Admin
 
Posts: 2175
Joined: Thu Jun 08, 2006 9:07 pm

Return to Genetics, Research, Lymphangiogenesis, Angiogenesis

Who is online

Users browsing this forum: No registered users and 5 guests


cron